Abstract | OBJECTIVES: The aim of this study is to investigate antidiabetic effects and molecular mechanisms of the chemical Chikusetsu saponin IVa (CHS) that isolated from root bark of Aralia taibaiensis, which has multiple pharmacological activity, such as relieving rheumatism, promoting blood circulation to arrest pain and antidiabetic action. METHODS: KEY FINDINGS: CONCLUSIONS: CHS is a novel AMPK activator that is capable of bypassing defective insulin signalling and could be useful for the treatment of T2DM or other metabolic disorders.
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Authors | Yuwen Li, Tiejun Zhang, Jia Cui, Na Jia, Yin Wu, Miaomiao Xi, Aidong Wen |
Journal | The Journal of pharmacy and pharmacology
(J Pharm Pharmacol)
Vol. 67
Issue 7
Pg. 997-1007
(Jul 2015)
ISSN: 2042-7158 [Electronic] England |
PMID | 25677570
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 Royal Pharmaceutical Society. |
Chemical References |
- Blood Glucose
- Fatty Acids
- Fatty Acids, Nonesterified
- Hypoglycemic Agents
- Hypolipidemic Agents
- Insulin
- Saponins
- Triglycerides
- chikusetsu saponin IVa
- Streptozocin
- Oleanolic Acid
- Glucose
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Topics |
- Animals
- Aralia
(chemistry)
- Blood Glucose
(drug effects)
- Diabetes Mellitus, Experimental
(blood, drug therapy, metabolism)
- Diabetes Mellitus, Type 2
(blood, chemically induced, drug therapy, metabolism)
- Fatty Acids
(metabolism)
- Fatty Acids, Nonesterified
(blood)
- Glucose
(metabolism)
- Hypoglycemic Agents
(pharmacology)
- Hypolipidemic Agents
(pharmacology)
- Insulin
(metabolism)
- Insulin Resistance
(physiology)
- Male
- Oleanolic Acid
(analogs & derivatives, pharmacology)
- Oxidation-Reduction
(drug effects)
- Plant Bark
(chemistry)
- Plant Roots
(chemistry)
- Rats
- Rats, Wistar
- Saponins
(pharmacology)
- Streptozocin
(pharmacology)
- Triglycerides
(blood)
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