Expect the Unexpected: Report of a Case of Pediatric Pharyngeal Extraosseous Plasmacytoma with Tumefactive Amyloidosis ("Amyloidoma") and a Review of the Literature.

Abstract

We report a rare case of localized pharyngeal tumefactive amyloidosis caused by extraosseous plasmacytoma in a 12 year-old girl who presented with otalgia, sore throat and blood stained sputum. The tumor was predominantly composed of amyloid with a limited component of well-differentiated neoplastic plasma cells, which were monoclonal (kappa restricted) on light chain in-situ hybridization. The amyloid deposits were positive for kappa immunoglobulin light chain on immunohistochemistry. The patient was treated with a combination of surgery and radiotherapy. Follow-up at 1 year showed no evidence of recurrence or progression.

• Authors: Char Loo Tan, Sze Hwa Tan, Siok Bian Ng, Fredrik Petersson
• Journal: Head and neck pathology (Head Neck Pathol) Vol. 9 Issue 4 Pg. 431-5 (Dec 2015) ISSN: 1936-0568 [Electronic] United States
• PMID: 25672253 (Publication Type: Case Reports, Journal Article, Review)

Topics

• Amyloidosis (etiology, pathology, therapy)
• Child
• Combined Modality Therapy
• Digestive System Surgical Procedures
• Female
• Humans
• Pharyngeal Neoplasms (complications, pathology, therapy)
• Plasmacytoma (complications, pathology, therapy)
• Radiotherapy