[Protein quality control and psychiatric disorder--involvement of sigma-1 receptor].

The protein quality control mechanism in the endoplasmic reticulum is referred to as the unfolded protein response (UPR), and its failure may be involved in the onset of some psychiatric disorders. We showed that induction of the sigma-1 receptor plays a role in the UPR, and suggested the possibility that this mechanism is impaired in disorders such as schizophrenia. We also demonstrated that fluvoxamine induces expression of the sigma-1 receptor. Therefore, it has the potential to be developed as a drug which exerts an anti-ER-stress effect, i. e., protein quality control effect.
AuthorsTakashi Kudo
JournalSeishin shinkeigaku zasshi = Psychiatria et neurologia Japonica (Seishin Shinkeigaku Zasshi) Vol. 116 Issue 10 Pg. 859-65 ( 2014) ISSN: 0033-2658 [Print] Japan
PMID25672212 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Receptors, sigma
  • sigma-1 receptor
  • Fluvoxamine
  • Animals
  • Endoplasmic Reticulum (metabolism)
  • Fluvoxamine (metabolism)
  • Humans
  • Mental Disorders (metabolism)
  • Protein Unfolding
  • Receptors, sigma (metabolism)
  • Signal Transduction

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