Abstract | BACKGROUND: METHODS: This randomized control trial was done at the Kidney Centre, Post Graduate Training Institute (PGTi), Karachi, Pakistan between 15 January 2010 till 31st December 2010 to compare the efficacy and safety of, CPS and SPS in 97 CKD patients with hyperkalemia. The subjects were divided in two groups. Group-A received CPS while group-B received SPS. The data included symptoms, food recall, physical signs of volume overload and electrolytes. After receiving potassium binding resin for 3 days patients were evaluated for symptoms, weight gain, worsening of blood pressure and effect on electrolytes. Adverse events were recorded in an event reporting form. RESULTS: Average potassium level pre resin was 5.8_0.26 in group-A and 5.8±0.6 in group-B, which reduced to 4.8±0.5 in group-A and 4.3±0.53 in group-B suggesting the efficacy of both drugs for treatment of hyperkalemia in CKD patients. Systolic blood pressure remains stable in both the groups while an increase in diastolic blood pressure was noticed in group-B patients (p-value 0.004). No major adverse effect occurred in both the groups. CONCLUSION: Both CPS and SPS can be used effectively for reducing hyperkalemia of CKD. CPS showed fewer side effects as compared to SPS.
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Authors | Kiran Nasir, Aasim Ahmad |
Journal | Journal of Ayub Medical College, Abbottabad : JAMC
(J Ayub Med Coll Abbottabad)
2014 Oct-Dec
Vol. 26
Issue 4
Pg. 455-8
ISSN: 1025-9589 [Print] Pakistan |
PMID | 25672163
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Chelating Agents
- Polystyrenes
- polystyrene sulfonic acid
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Topics |
- Adult
- Aged
- Chelating Agents
(adverse effects, therapeutic use)
- Female
- Humans
- Hyperkalemia
(drug therapy, etiology)
- Male
- Middle Aged
- Polystyrenes
(adverse effects, therapeutic use)
- Renal Insufficiency, Chronic
(complications)
- Single-Blind Method
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