Activities of dipeptidyl peptidase II and dipeptidyl peptidase IV in synovial fluid from patients with rheumatoid arthritis and osteoarthritis.

Abstract

We examined the activities of peptidases in synovial fluid from patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Dipeptidyl peptidase IV (DPP IV) activity was lower in synovial fluid from patients with RA, in contrast to the increase of DPP II activity in synovial fluid, as compared with OA. The DPP II/DPP IV ratio for synovial fluid was significantly higher in patients with RA than in patients with OA. A significant correlation was observed between the DPP II/DPP IV ratio for synovial fluid from patients with RA and the amount of C-reactive protein reaction. These results may be useful in the diagnosis of joint effusion of unknown origin.

• Authors: H Gotoh, M Hagihara, T Nagatsu, H Iwata, T Miura
• Journal: Clinical chemistry (Clin Chem) Vol. 35 Issue 6 Pg. 1016-8 (Jun 1989) ISSN: 0009-9147 [Print] England
• PMID: 2567214 (Publication Type: Journal Article)

Chemical References

• Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
• dipeptidyl peptidase II
• Dipeptidyl Peptidase 4
• Serine Endopeptidases
• PREPL protein, human
• Prolyl Oligopeptidases

Topics

• Arthritis, Rheumatoid (enzymology)
• Dipeptidyl Peptidase 4
• Dipeptidyl-Peptidases and Tripeptidyl-Peptidases (metabolism)
• Humans
• Osteoarthritis (enzymology)
• Prolyl Oligopeptidases
• Serine Endopeptidases (metabolism)
• Synovial Fluid (enzymology)