Abstract | PURPOSE: METHODS: This was a cohort study of 81 subjects who were assessed before and after treatment. Spectral-domain optical coherence tomography (SD-OCT) was used to quantify CME. A reduction of at least 11% in central subfield (CSF) thickness was defined as objective evidence of response. RESULTS: In the 125 eyes that received topical dorzolamide, 40.0% demonstrated a response to treatment with a mean reduction in OCT CSF thickness of 105 μm (95% confidence interval [CI]: 82, 128). Mean starting visual acuity (VA) increased from 6/15 to 6/12 after a median time on treatment of 3.0 months. In patients prescribed oral acetazolamide, 28.1% of eyes (41.2% of patients) showed improvement in mean OCT CSF thickness of 115 μm (95% CI: 52, 177) over a median treatment interval of 4.0 months. Visual acuity improved from 6/15 to 6/12. Eyes that responded to topical dorzolamide were more likely to have autosomal recessive than autosomal dominant RP (44.6% vs. 23.3%, P = 0.02), and a higher mean baseline OCT CSF than eyes that did not respond (P = 0.02). CONCLUSIONS:
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Authors | Gerald Liew, Anthony T Moore, Andrew R Webster, Michel Michaelides |
Journal | Investigative ophthalmology & visual science
(Invest Ophthalmol Vis Sci)
Vol. 56
Issue 3
Pg. 1531-6
(Feb 10 2015)
ISSN: 1552-5783 [Electronic] United States |
PMID | 25670491
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2015 The Association for Research in Vision and Ophthalmology, Inc. |
Chemical References |
- Carbonic Anhydrase Inhibitors
- Delayed-Action Preparations
- Ophthalmic Solutions
- Sulfonamides
- Thiophenes
- dorzolamide
- Acetazolamide
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Topics |
- Acetazolamide
(therapeutic use)
- Administration, Oral
- Adult
- Carbonic Anhydrase Inhibitors
(therapeutic use)
- Cohort Studies
- Delayed-Action Preparations
- Drug Administration Schedule
- Female
- Humans
- Macular Edema
(diagnosis, drug therapy)
- Male
- Middle Aged
- Ophthalmic Solutions
- Retinitis Pigmentosa
(diagnosis, drug therapy)
- Retrospective Studies
- Sulfonamides
(therapeutic use)
- Thiophenes
(therapeutic use)
- Tomography, Optical Coherence
- Treatment Outcome
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