Abstract | BACKGROUND: OBJECTIVE: METHODS: In a double-blind, randomized, crossover design (21-day treatments, 21-day washout between), 4 tablespoons/day CO or EVOO were provided in 3 servings study product/day (muffin, roll, yogurt) as part of a weight-maintenance diet (∼35% fat, <10% saturated fat, <300 mg cholesterol). Subjects ate breakfast at the clinic every weekday throughout the study. Lunches, dinners, and snacks (and breakfasts on weekends) were provided for consumption away from the clinic. RESULTS: Baseline mean (standard error) lipids in mg/dL were: LDL-C 153.3 (3.5), total cholesterol (total-C) 225.7 (3.9), non- high-density lipoprotein (non-HDL)-C 178.3 (3.7), HDL-C 47.4 (1.7), total-C/HDL-C 5.0 (0.2), and TG 124.8 (7.2). CO resulted in significantly larger least-squares mean % changes (all P < .001 vs EVOO) from baseline in LDL-C -10.9 vs -3.5, total-C -8.2 vs -1.8, non-HDL-C -9.3 vs -1.6, and total-C/HDL-C -4.4 vs 0.5. TG rose a smaller amount with CO, 3.5 vs 13.0% with EVOO (P = .007). HDL-C responses were not significantly different between conditions (-3.4 vs -1.7%). CONCLUSION: Consumption of CO in a weight-maintenance, low saturated fat and cholesterol diet resulted in more favorable changes in LDL-C and other atherogenic lipids vs EVOO.
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Authors | Kevin C Maki, Andrea L Lawless, Kathleen M Kelley, Valerie N Kaden, Constance J Geiger, Mary R Dicklin |
Journal | Journal of clinical lipidology
(J Clin Lipidol)
2015 Jan-Feb
Vol. 9
Issue 1
Pg. 49-57
ISSN: 1933-2874 [Print] United States |
PMID | 25670360
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 National Lipid Association. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Cholesterol, LDL
- Lipids
- Lipoproteins, HDL
- Olive Oil
- Plant Oils
- Corn Oil
- Cholesterol
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Topics |
- Adolescent
- Adult
- Aged
- Blood Pressure
- Body Weight
- Cholesterol
(blood)
- Cholesterol, LDL
(blood)
- Corn Oil
(administration & dosage)
- Cross-Over Studies
- Double-Blind Method
- Female
- Humans
- Hypercholesterolemia
(pathology)
- Lipids
(blood)
- Lipoproteins, HDL
(blood)
- Male
- Middle Aged
- Olive Oil
- Plant Oils
(administration & dosage)
- Treatment Outcome
- Young Adult
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