Mathematical modelling of the transmission dynamics of contagious bovine pleuropneumonia reveals minimal target profiles for improved vaccines and diagnostic assays.

Abstract	Contagious bovine pleuropneumonia (CBPP) is a cattle disease that has hampered the development of the livestock sector in sub-Saharan Africa. Currently, vaccination with a live vaccine strain is its recommended control measure although unofficial antimicrobial use is widely practiced. Here, modelling techniques are used to assess the potential impact of early elimination of infected cattle via accurate diagnosis on CBPP dynamics. A herd-level stochastic epidemiological model explicitly incorporating test sensitivity and specificity is developed. Interventions by annual vaccination, annual testing and elimination and a combination of both are implemented in a stepwise manner and their effectiveness compared by running 1000 simulations per intervention over ten years. The model predicts that among the simulated interventions, the ones likely to eliminate the disease from an isolated herd all involved annual vaccination of more than 75% of the animals with a vaccine that protects for at least 18 months combined with annual testing (and elimination of positive reactors) of 75% of the animals every six months after vaccination. The highest probability of disease elimination was 97.5% and this could occur within a median of 2.3 years. Generally, our model predicts that regular testing and elimination of positive reactors using improved tests will play a significant role in minimizing CBPP burden especially in the current situation where improved vaccines are yet to be developed.
Authors	Amos Ssematimba, Joerg Jores, Jeffrey C Mariner
Journal	PloS one (PLoS One) Vol. 10 Issue 2 Pg. e0116730 ( 2015) ISSN: 1932-6203 [Electronic] United States
PMID	25668725 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Bacterial Vaccines
Topics	Africa South of the Sahara Animals Bacterial Vaccines (administration & dosage) Cattle Cattle Diseases (diagnosis, prevention & control) Disease Transmission, Infectious (prevention & control) Models, Theoretical Pleuropneumonia, Contagious (diagnosis, prevention & control) Sensitivity and Specificity Vaccination (veterinary)

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