Flavonolignans and other constituents from Lepidium meyenii with activities in anti-inflammation and human cancer cell lines.

Abstract

From the roots of Lepidium meyenii Walpers (Brassicaceae) have been isolated and identified 2 flavonolignans, tricin 4'-O-[threo-β-guaiacyl-(7″-O-methyl)-glyceryl] ether (1) and tricin 4'-O-(erythro-β-guaiacyl-glyceryl) ether (2), along with 11 other known compounds, tricin (3), pinoresinol (4), 4-hydroxycinnamic acid (5), guanosine (6), glucotropaeolin (7), desulfoglucotropaeolin (8), 3-hydroxybenzylisothiocyanate (9), malic acid benzoate (10), 5-(hydroxymethyl)-2-furfural (11), d-phenylalanine (12), and vanillic acid 4-O-β-d-glucoside (13). Structures were elucidated on the basis of NMR and MS data. Some isolates and previously isolated lepidiline B (14) were tested for cytotoxicity in a small panel of human cancer cell lines (Hep G2, COLO 205, and HL-60) and for anti-inflammatory activities in LPS-treated RAW 264.7 macrophage. Among them, compounds 1 and 14 were modestly active for inhibiting nitrite production in macrophage. Compounds 1, 14, and 3 were demonstrated to be selectively active against HL-60 cells with IC50 values of 40.4, 52.0, and 52.1 μM, respectively.

• Authors: Naisheng Bai, Kan He, Marc Roller, Ching-Shu Lai, Lu Bai, Min-Hsiung Pan
• Journal: Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 63 Issue 9 Pg. 2458-63 (Mar 11 2015) ISSN: 1520-5118 [Electronic] United States
• PMID: 25667964 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Antineoplastic Agents, Phytogenic
• Flavonolignans
• Plant Extracts

Topics

• Animals
• Anti-Inflammatory Agents (chemistry, pharmacology)
• Antineoplastic Agents, Phytogenic (chemistry, pharmacology)
• Cell Line, Tumor
• Flavonolignans (chemistry, pharmacology)
• Humans
• Lepidium (chemistry)
• Macrophages (drug effects, immunology)
• Mice
• Plant Extracts (chemistry, pharmacology)