Design, synthesis and evaluation of a novel class of glucosamine mimetic peptides containing 1,3-dioxane.

Abstract

A number of novel 2-(N-(2-(5,5-dimethyl-1,3-dioxane-2-yl)ethyl)aminoacyl)amino-2-deoxy- d-glucopyranoside were synthesized from a readily available starting material, glucosamine, 2,2-dimethyl-1,3-propanediol and 1,1,3,3-tetramethoxypropane, and evaluated for their anti-inflammatory activity. Our results showed that all of the compounds tested exhibited a significant inhibition of xylene-induced inflammation in mice.

• Authors: Li Zeng, Guichao Xu, Pengchao Gao, Meng Zhang, Hong Li, Jianwei Zhang
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 93 Pg. 109-20 (Mar 26 2015) ISSN: 1768-3254 [Electronic] France
• PMID: 25666911 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Chemical References

• Anti-Inflammatory Agents
• Dioxanes
• Peptidomimetics
• Glucosamine

Topics

• Animals
• Anti-Inflammatory Agents (chemical synthesis, chemistry, pharmacology, therapeutic use)
• Dioxanes (chemistry)
• Drug Design
• Edema (drug therapy)
• Glucosamine (chemistry)
• Male
• Mice
• Mice, Inbred ICR
• Molecular Structure
• Peptidomimetics (chemical synthesis, chemistry, pharmacology, therapeutic use)