[Indications for methotrexate in gynecology outside the first-line treatment of ectopic tubal pregnancies].

Abstract

The objective of this work is to discuss the indications for methotrexate in gynecology outside the first-line treatment of tubal ectopic pregnancy. In tubal ectopic pregnancy, the prophylactic use of systemic methotrexate can be discussed when performing laparoscopic salpingotomy. In case of failure of salpingotomy, administration seems justified especially if it avoids re-intervention. The combination of methotrexate with other therapies such as mifepristone, potassium chloride or gefitinib is not recommended in the treatment of ectopic pregnancy. For non-tubal ectopic pregnancy, the intramuscular or local administration of methotrexate is an acceptable treatment for uncomplicated interstitial pregnancies. For uncomplicated cervical or cesarean scar pregnancies, the local administration of methotrexate should be considered as a first-line treatment. For ovarian pregnancies, methotrexate should not be a first-line treatment, surgical treatment remains the standard. Asymptomatic women presenting with a pregnancy of unknown location and plateauing serum hCG concentration<2000 UI/L can be managed expectantly: it is recommended to take an additional quantitative hCG serum level after 48 hours. Thus, methotrexate is not recommended in the first intention. Other gynecological indications were discussed: methotrexate is not recommended in the management of first-trimester miscarriages or in the management of placenta accreta.

• Authors: H Misme, A Agostini, G Dubernard, C Tourette
• Journal: Journal de gynecologie, obstetrique et biologie de la reproduction (J Gynecol Obstet Biol Reprod (Paris)) Vol. 44 Issue 3 Pg. 220-9 (Mar 2015) ISSN: 1773-0430 [Electronic] France
• Vernacular Title: Indications du méthotrexate en gynécologie en dehors du traitement de première intention des grossesses extra-utérines tubaires.
• PMID: 25666162 (Publication Type: English Abstract, Journal Article, Review)
• Copyright: Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Chemical References

• Abortifacient Agents, Nonsteroidal
• Chorionic Gonadotropin
• Methotrexate

Topics

• Abortifacient Agents, Nonsteroidal (therapeutic use)
• Chorionic Gonadotropin (blood)
• Female
• Humans
• Methotrexate (therapeutic use)
• Pregnancy
• Pregnancy, Ectopic (blood, drug therapy)