Effect of Letrozole on endometriosis-related pelvic pain.

Abstract

BACKGROUND:

To determine the role of Letrozole, an aromatase inhibitor, in the treatment of endometriotic pain.

METHODS:

In this prospective, randomized, controlled clinical trial in minimally invasive surgery research center, 51 women with pelvic endometriosis and endometriotic pain (dyspareunia, dysmenorrhea, pelvic pain) score of 5 or more (for at least one of these endometriotic pain), after laparoscopic diagnosis and conservative laparoscopic surgery were treated with either Letrozole plus OCP (n=25) or only OCP (n=26) for 4 months continuously.

RESULTS:

Using VAS test, the score of dyspareunia, dysmenorrhea and pelvic pain 4 months after the laparoscopic surgery declined significantly in both groups but the difference between results of the two groups was not significant.

CONCLUSION:

Both treatment modalities showed comparable effectiveness in the treatment of pains related to endometriosis and in comparison with OCP, Letrozole did not affect the outcome.

• Authors: Fariba Almassinokiani, Alireza Almasi, Peyman Akbari, Mahboubeh Saberifard
• Journal: Medical journal of the Islamic Republic of Iran (Med J Islam Repub Iran) Vol. 28 Pg. 107 ( 2014) ISSN: 1016-1430 [Print] Iran
• PMID: 25664308 (Publication Type: Journal Article)