Antiviral effect of lithium chloride on infection of cells by porcine parvovirus.

Abstract

Porcine parvovirus (PPV) causes reproductive failure in pigs, which leads to economic losses to the industry. As reported previously, LiCl efficiently impairs the replication of a variety of viruses, including the coronavirus infectious bronchitis virus (IBV), transmissible gastroenteritis virus (TGEV), and pseudorabies herpesvirus. We demonstrate for the first time that inhibition of PPV replication in swine testis (ST) cells by LiCl is dose-dependent, and that the antiviral effect of LiCl occurred in the early phase of PPV replication. These results indicate that LiCl might be an effective anti-PPV drug to control PPV disease. Further studies are required to explore the mechanism of the antiviral effect of LiCl on PPV infection in vivo.

• Authors: Ye Chen, Huichao Yan, Hao Zheng, Yuzhen Shi, Lingsuang Sun, Chong Wang, Jingchen Sun
• Journal: Archives of virology (Arch Virol) Vol. 160 Issue 4 Pg. 1015-20 (Apr 2015) ISSN: 1432-8798 [Electronic] Austria
• PMID: 25663217 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• Lithium Chloride

Topics

• Animals
• Antiviral Agents (pharmacology)
• Cell Line
• Lithium Chloride (pharmacology)
• Parvoviridae Infections (veterinary, virology)
• Parvovirus, Porcine (drug effects, genetics, physiology)
• Swine
• Swine Diseases (virology)
• Virus Attachment (drug effects)
• Virus Replication (drug effects)