Abstract |
Six cases of systemic reactions to topical treatment with beta-blocking eyedrops are reported, bradycardia and faintness due to an overdosage of ophthalmic timolol; decompensated heart failure one month after the prescription of carteolol eyedrops: bronchospasm after two weeks of treatment with metipranolol eyedrops; crippling Raynaud's phenomenon of otherwise unknown origin, which had begun with timolol eyedrops, continued with carteolol eyedrops and regressed after discontinuation of ophthalmic beta-blockers; aggravation of an anaphylactoid shock in a patient treated with ophthalmic timolol, and myocardial infarction possibly due to the abrupt withdrawal of timolol eyedrops. It cannot be overstressed that the rules governing the prescription of oral beta-blockers also apply to ophthalmic preparations of these drugs: respect of contra-indications, strict adherence to the dosage recommended, gradual drug withdrawal and regular supervision. Only controlled studies and long-term follow-up will be able to demonstrate differences in safety between the five beta-blockers commercialized as eyedrops in this country.
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Authors | H Vinti, R M Chichmanian, J P Fournier, A Pesce, B Taillan, J G Fuzibet, J P Cassuto, P Dujardin |
Journal | La Revue de medecine interne
(Rev Med Interne)
1989 Jan-Feb
Vol. 10
Issue 1
Pg. 41-4
ISSN: 0248-8663 [Print] France |
Vernacular Title | Accidents systémiques des bêta-bloquants en collyres. A propos de six observations. |
PMID | 2566193
(Publication Type: Case Reports, English Abstract, Journal Article, Review)
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Chemical References |
- Adrenergic beta-Antagonists
- Ophthalmic Solutions
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Topics |
- Adrenergic beta-Antagonists
(adverse effects)
- Aged
- Aged, 80 and over
- Bronchial Spasm
(chemically induced)
- Drug Interactions
- Female
- Heart Rate
(drug effects)
- Humans
- Male
- Middle Aged
- Ophthalmic Solutions
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