Fulminant endocarditis and disseminated infection caused by carbapenem-resistant Acinetobacter baumannii in a renal-pancreas transplant recipient.

Abstract

Acinetobacter baumannii is an important cause of healthcare-associated infections, and is particularly problematic among patients who undergo organ transplantation. We describe a case of fulminant sepsis caused by carbapenem-resistant A. baumannii harboring the blaOXA-23 carbapenemase gene and belonging to international clone II. This isolate led to the death of a patient 6 days after simultaneous kidney-pancreas transplantation. Autopsy findings revealed acute mitral valve endocarditis, myocarditis, splenic and renal emboli, peritonitis, and pneumonia. This case highlights the severe nature of certain A. baumannii infections and the vulnerability of transplanted patients to the increasingly intractable "high-risk" clones of multidrug-resistant organisms.

• Authors: G Patel, F Perez, A M Hujer, S D Rudin, J J Augustine, G H Jacobs, M R Jacobs, R A Bonomo
• Journal: Transplant infectious disease : an official journal of the Transplantation Society (Transpl Infect Dis) Vol. 17 Issue 2 Pg. 289-96 (Apr 2015) ISSN: 1399-3062 [Electronic] Denmark
• PMID: 25661804 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Bacterial Proteins
• Carbapenems
• beta-Lactamases
• carbapenemase

Topics

• Acinetobacter Infections
• Acinetobacter baumannii (genetics)
• Bacteremia
• Bacterial Proteins (genetics)
• Carbapenems
• Diabetes Mellitus, Type 1 (surgery)
• Drug Resistance, Bacterial (genetics)
• Endocarditis, Bacterial
• Humans
• Kidney Failure, Chronic (surgery)
• Kidney Transplantation
• Male
• Middle Aged
• Pancreas Transplantation
• Postoperative Complications
• beta-Lactamases (genetics)