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The involvement of FAK-PI3K-AKT-Rac1 pathway in porcine reproductive and respiratory syndrome virus entry.

Abstract
CD163 and sialoadhesin had been reported as the two receptors for porcine reproductive and respiratory syndrome virus (PRRSV) infection. The signaling pathway activated by PRRSV entry was seldom reported. In our studies, we demonstrated that PRRSV entry triggers FAK, PI3K, AKT and Rac1 activation. The signaling pathway FAK-PI3K-AKT-Rac1 is essential for PRRSV entry. Blocking FAK by PF573228 attenuates the activation of PI3K, AKT, Rac1 and the cytoskeleton remodeling induced by virus entry. Inhibitors to FAK, PI3K, AKT and Rac1 can significantly inhibit the virus entry. In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.
AuthorsBo Ni, Li-Bin Wen, Rui Wang, Hong-Ping Hao, Chang-Chao Huan, Xin Wang, Li Huang, Jin-Feng Miao, Hong-Jie Fan, Xiang Mao
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 458 Issue 2 Pg. 392-8 (Mar 06 2015) ISSN: 1090-2104 [Electronic] United States
PMID25660453 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier Inc. All rights reserved.
Chemical References
  • Phosphotransferases
  • Phosphatidylinositol 3-Kinases
  • Focal Adhesion Kinase 1
  • Oncogene Protein v-akt
  • rac1 GTP-Binding Protein
Topics
  • Animals
  • Focal Adhesion Kinase 1 (metabolism)
  • Oncogene Protein v-akt (metabolism)
  • Phosphatidylinositol 3-Kinases (metabolism)
  • Phosphotransferases (metabolism)
  • Porcine Reproductive and Respiratory Syndrome (enzymology, virology)
  • Porcine respiratory and reproductive syndrome virus (physiology)
  • Signal Transduction
  • Swine (metabolism, virology)
  • Virus Internalization
  • rac1 GTP-Binding Protein (metabolism)

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