Human leukocyte antigen-G polymorphism influences the age of onset and autoantibody status in rheumatoid arthritis.

Abstract

The study was conducted to investigate the frequency of three gene polymorphisms in the 3'-untranslated region (3'-UTR) of human leucocyte antigen-G (HLA-G) gene in south Indian patients with rheumatoid arthritis (RA) and analyze their influence on disease susceptibility, phenotype and treatment response. HLA-G 14 bp insertion (Ins)/deletion (del) (rs66554220), HLA-G +3142G>C (rs1063320) and +3187A>G (rs9380142) polymorphism was analyzed in 221 RA patients and 200 healthy controls. Frequency of HLA-G genotypes or alleles did not differ between patients and controls. Analysis based on rheumatoid factor (RF) status revealed that the frequency of allele 'A' (rs9380142) was significantly higher in RF-positive than in RF-negative patients [84% vs 74%, Yates-corrected P value (Pc) = 0.04, odds ratio (OR) = 1.8, 95% confidence interval (CI) = 1.0-3.2]. A similar difference was maintained in RF-positive female patients than their RF-negative counterparts (83% vs 71%, Pc = 0.02, OR = 1.9, 95% CI = 1.0 to 3.4) and between RF-positive and RF-negative young onset RA (YORA) patients (84% vs 73%, Pc = 0.03, OR = 1.9, 95% CI = 1.0-3.2), suggesting that rs9380142 polymorphism influenced RF status. The 14 bp Ins allele of rs66554220 was significantly more prevalent in RF-positive YORA than in RF-positive late onset RA (LORA) patients (51% vs 25%, P = 0.03, OR = 3.1, 95% CI = 1.1-9.8). Frequency of the four major haplotypes [InsGA (48%), DelGA (22%), DelCG (18%), DelCA (9.7%)] observed did not differ between cases and controls. HLA-G does not appear to be a risk factor for development of RA in south Indian Tamils but may act as a genetic modifier of clinical phenotype in terms of autoantibody production, gender preference and age at disease onset.

• Authors: C M Mariaselvam, A B Chaaben, S Salah, D Charron, R Krishnamoorthy, R Tamouza, V S Negi
• Journal: Tissue antigens (Tissue Antigens) Vol. 85 Issue 3 Pg. 182-9 (Mar 2015) ISSN: 1399-0039 [Electronic] England
• PMID: 25656292 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• 3' Untranslated Regions
• Autoantibodies
• HLA-G Antigens
• Rheumatoid Factor

Topics

• 3' Untranslated Regions
• Adult
• Age of Onset
• Alleles
• Arthritis, Rheumatoid (epidemiology, genetics, immunology, pathology)
• Autoantibodies (blood)
• Case-Control Studies
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• HLA-G Antigens (genetics, immunology)
• Haplotypes
• Humans
• India (epidemiology)
• Male
• Middle Aged
• Polymorphism, Genetic
• Rheumatoid Factor (genetics, immunology)
• Risk Factors
• Sex Factors