Increased seizure susceptibility induced by guanidinoethane sulfonate in E1 mice and its relation to glutamatergic neurons.

Abstract

Convulsions and brain levels of amino acids and 5-hydroxytryptamine (5-HT) in E1 mice were examined after oral administration of a 1% guanidinoethane sulfonate (GES) solution. The incidence of convulsions increased 3 days after starting GES administration, and this effect continued throughout the 6 months of drug administration. Glutamate levels were increased in the cerebrum, and glutamine levels were increased in the cerebellum three days after starting GES administration. Brain 5-HT levels were not changed at that time. These results suggest that increased seizure susceptibility induced by GES in E1 mice is related to glutamatergic neurons.

• Authors: M Hiramatsu, R Edamatsu, H Kabuto, Y Higashihara, A Mori
• Journal: Neurochemical research (Neurochem Res) Vol. 14 Issue 1 Pg. 85-9 (Jan 1989) ISSN: 0364-3190 [Print] United States
• PMID: 2565540 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Convulsants
• Glutamates
• Glutamine
• Taurine
• Serotonin
• Glutamic Acid
• taurocyamine

Topics

• Animals
• Convulsants (pharmacology)
• Glutamates (metabolism)
• Glutamic Acid
• Glutamine (metabolism)
• Mice
• Seizures (chemically induced, metabolism, physiopathology)
• Serotonin (metabolism)
• Taurine (analogs & derivatives, pharmacology)