The use of
phosphate mineral products in animal nutrition, as a major source of phosphor and
calcium, can lead to
uranium entering the food chain. The aim of the present study was to determine the protective effect of natural
sepiolite and
sepiolite treated with
acid for broilers after oral intake of
uranium. The broilers were contaminated for 7 days with 25 mg/
uranyl nitrate per day. Two different adsorbents (natural
sepiolite and
sepiolite treated with
acid) were given via gastric tube immediately after the
oral administration of
uranium. Natural
sepiolite reduced
uranium distribution by 57% in kidney, 80% in liver, 42% in brain, and 56% in muscle. A lower protective effect was observed after the administration of
sepiolite treated with
acid, resulting in significant damage of intestinal villi in the form of shortening, fragmentation, and
necrosis, and histopathological lesions on kidney in the form of
edema and abruption of epithelial cells in tubules. When broilers received only
sepiolite treated with
acid (no
uranyl nitrate), shortening of intestinal villi occurred. Kidney
injuries were evident when
uranium concentrations in kidney were 0.88 and 1.25 µg/g dry weight. It is concluded that adding of natural
sepiolite to the diets of broilers can reduce
uranium distribution in organs by significant amount without adverse side effects.