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Symptomatic factor XIII deficiency with normal urea solubility test.

AbstractBACKGROUND:
Factor XIII deficiency is a rarely encountered bleeding disorder traditionally identified by clot dissolution in 5 molar urea (urea solubility test).
METHODS:
We report a patient with delayed post-surgical bleeding characteristic of factor XIII deficiency with a normal urea solubility test.
RESULTS:
Factor XIII deficiency was identified by an automated assay that measured factor XIII antigen. The patient was successfully treated with cryoprecipitate.
CONCLUSIONS:
Patients with excessive bleeding with normal screening tests should be tested for factor XIII using a sensitive assay procedure. The urea solubility assay for factor XIII should be discontinued due to its lack of sensitivity.
AuthorsMichael J Sanfelippo, Joseph J Mazza, Richard J Mercier
JournalClinical laboratory (Clin Lab) Vol. 60 Issue 12 Pg. 2099-102 ( 2014) ISSN: 1433-6510 [Print] Germany
PMID25651747 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Urea
Topics
  • Aged, 80 and over
  • Blood Coagulation
  • Blood Coagulation Tests (methods)
  • Cardiac Surgical Procedures (adverse effects)
  • Factor XIII Deficiency (blood, complications, diagnosis)
  • Humans
  • Male
  • Postoperative Hemorrhage (etiology, therapy)
  • Predictive Value of Tests
  • Solubility
  • Treatment Outcome
  • Urea

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