Historical series of patients with visceral leishmaniasis treated with meglumine antimoniate in a hospital for tropical diseases, Maceió-AL, Brazil.

Abstract

INTRODUCTION:

Visceral leishmaniasis is an endemic protozoan found in Brazil. It is characterized by fever, pallor, hepatosplenomegaly, lymphadenopathy, and progressive weakness in the patient. It may lead to death if untreated. The drug of choice for treatment is meglumine antimoniate (Glucantime). The aim of this study was to evaluate patients with visceral leishmaniasis according to criteria used for diagnosis, possible reactions to Glucantime and blood pressure measured before and after treatment.

METHODS:

89 patients admitted to the Teaching Hospital Dr. Hélvio Auto (HEHA) in Maceió-AL, in the period from May 2006 to December 2009 were evaluated. Data were collected on age, sex, origin, method of diagnosis, adverse effects of drugs, duration of hospitalization, duration of treatment and dosage up to the onset of adverse effects.

RESULTS:

There was a predominance of child male patients, aged between one and five years old, from the interior of the State of Alagoas. Parasitological diagnosis was made by bone marrow aspirate; three (3.37%) patients died, 12 (13.48%) had adverse reactions and treatment was changed to amphotericin B, and 74 (83.14%) were cured. Changes that led to replacing Glucantime were persistent fever, jaundice, rash, bleeding and cyanosis.

CONCLUSION:

During the study, 89 patients hospitalized for VL were analyzed: 74 were healed, 12 were replaced by amphotericin B treatment and three died. Most of them were under five years old, male and came from the interior. The dosage and duration of treatment with Glucantime were consistent with that advocated by the Ministry of Health. Persistence of fever, jaundice, rash, cyanosis and bleeding were the reactions that led the physician to modify treatment. No change was observed in blood pressure before and after treatment. This study demonstrated the work of a hospital, a reference in the treatment of leishmaniasis, which has many patients demanding its services in this area. It demonstrates that this disease is still important today, and needs to be addressed properly to prevent injury and death due to the disease.

• Authors: Lindon Johoson Diniz Silveira, Thiago José Matos Rocha, Sandra Aparecida Ribeiro, Célia Maria Silva Pedrosa
• Journal: Revista do Instituto de Medicina Tropical de Sao Paulo (Rev Inst Med Trop Sao Paulo) 2015 Jan-Feb Vol. 57 Issue 1 Pg. 33-8 ISSN: 1678-9946 [Electronic] Brazil
• PMID: 25651324 (Publication Type: Journal Article, Observational Study)

Chemical References

• Antiprotozoal Agents
• Organometallic Compounds
• Meglumine
• Meglumine Antimoniate
• Amphotericin B

Topics

• Adolescent
• Adult
• Aged
• Amphotericin B (adverse effects, therapeutic use)
• Antiprotozoal Agents (adverse effects, therapeutic use)
• Brazil
• Child
• Child, Preschool
• Cross-Sectional Studies
• Female
• Humans
• Infant
• Leishmaniasis, Visceral (drug therapy)
• Male
• Meglumine (adverse effects, therapeutic use)
• Meglumine Antimoniate
• Middle Aged
• Organometallic Compounds (adverse effects, therapeutic use)
• Treatment Outcome
• Young Adult