Abstract | INTRODUCTION AND OBJECTIVES: METHODS: We used an economic model based on the Spanish National Health System, with a time horizon of 24 weeks. Patient characteristics and ferric carboxymaltose effectiveness (quality-adjusted life years) were taken from the Ferinject® Assessment in patients with IRon deficiency and chronic Heart Failure trial. Health care resource use and unit costs were taken either from Spanish sources, or from the above mentioned trial. RESULTS: In the base case analysis, patients treated with and without ferric carboxymaltose treatment acquired 0.335 and 0.298 quality-adjusted life years, respectively, representing a gain of 0.037 quality-adjusted life years for each treated patient. The cost per patient was €824.17 and €597.59, respectively, resulting in an additional cost of €226.58 for each treated patient. The cost of gaining 1 quality adjusted life year with ferric carboxymaltose was €6123.78. Sensitivity analyses confirmed the robustness of the model. The probability of ferric carboxymaltose being cost-effective (< €30 000 per quality-adjusted life year) and dominant (more effective and lower cost than no treatment) was 93.0% and 6.6%, respectively. CONCLUSIONS:
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Authors | Josep Comín-Colet, Darío Rubio-Rodríguez, Carlos Rubio-Terrés, Cristina Enjuanes-Grau, Florian S Gutzwiller, Stefan D Anker, Piotr Ponikowski |
Journal | Revista espanola de cardiologia (English ed.)
(Rev Esp Cardiol (Engl Ed))
Vol. 68
Issue 10
Pg. 846-51
(Oct 2015)
ISSN: 1885-5857 [Electronic] Spain |
PMID | 25649970
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved. |
Chemical References |
- Ferric Compounds
- ferric carboxymaltose
- Maltose
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Topics |
- Aged
- Anemia, Iron-Deficiency
(drug therapy, epidemiology, etiology)
- Cost-Benefit Analysis
- Drug Costs
- Female
- Ferric Compounds
(economics, therapeutic use)
- Follow-Up Studies
- Heart Failure
(complications, epidemiology)
- Humans
- Incidence
- Male
- Maltose
(analogs & derivatives, economics, therapeutic use)
- Spain
(epidemiology)
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