Chorea due to diabetic hyperglycemia and uremia: distinct clinical and imaging features.

Abstract

This study was undertaken to describe the clinical and imaging characteristics of patients with chorea associated with nonketotic hyperglycemia (C-NKH) in comparison with patients with chorea associated with uremia (C-URE). We retrospectively analyzed the clinical data of consecutive 10 C-NKH and five C-URE patients who were treated between January 1, 2001 and January 31, 2013. Women were more frequently affected by C-NKH (70% vs. 30%) and C-URE (80% vs. 20%) compared with men. The C-NKH patients demonstrated T1-hyperintense and inhomogeneous lesions in the basal ganglia, whereas C-URE patients demonstrated T2-hyperintense and homogeneous lesions in the basal ganglia. The mean time for chorea resolution after treatment was significantly shorter in C-NKH patients than in C-URE patients (4.4 ± 2.6 d vs. 73.8 ± 14.2 d, respectively; P = 0.005). The clinical and imaging features are remarkably different between C-NKH and C-URE patients, suggesting distinct pathogenic mechanisms.

• Authors: Young Jin Kim, Sang Joon Kim, Juyeon Kim, Mi-Jung Kim, Ki-Ju Kim, Hyukjun Yoon, Sung Reul Kim, Sun Ju Chung
• Journal: Movement disorders : official journal of the Movement Disorder Society (Mov Disord) Vol. 30 Issue 3 Pg. 419-22 (Mar 2015) ISSN: 1531-8257 [Electronic] United States
• PMID: 25649292 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 International Parkinson and Movement Disorder Society.

Topics

• Adult
• Aged
• Aged, 80 and over
• Brain (pathology)
• Chorea (diagnosis, etiology)
• Diabetes Complications (physiopathology)
• Female
• Follow-Up Studies
• Humans
• Hyperglycemia (complications, etiology)
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Retrospective Studies
• Uremia (complications)