Abstract | BACKGROUND:
Amyotrophic lateral sclerosis patients have significant respiratory abnormalities with incomplete understanding of respiratory control. This study analyzes electromyography (EMG) of the diaphragm (dEMG) using implanted diaphragm pacing (DP) electrodes. METHODS: Retrospective analysis of dEMG data were obtained during Institutional Review Board and US Food and Drug Administration approved trials. The electrodes were used to analyze epochs of dEMG during multiple respiratory cycles. RESULTS: Fifty-three patients were implanted. Thirty-six had bilateral dEMG assessments, 18 had continuous overnight readings with pulse oximetry, and 19 had serial analysis. Several findings revealed an alteration in the central respiratory drive including central apnea, hypoventilation, and hypercarbia. The electrodes showed unilateral dysfunction and demonstrated noninvasive ventilation suppression of diaphragm activity. DP can be used for serial monitoring, to decrease hypercarbia, improve sleep, and decrease atrophy. CONCLUSIONS:
|
Authors | Raymond P Onders, MaryJo Elmo, Cindy Kaplan, Bashar Katirji, Robert Schilz |
Journal | American journal of surgery
(Am J Surg)
Vol. 209
Issue 3
Pg. 451-6
(Mar 2015)
ISSN: 1879-1883 [Electronic] United States |
PMID | 25648901
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
|
Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Topics |
- Amyotrophic Lateral Sclerosis
(complications, physiopathology)
- Electric Stimulation Therapy
(methods)
- Electrodes, Implanted
- Electromyography
(methods)
- Follow-Up Studies
- Humans
- Respiratory Insufficiency
(etiology, physiopathology, therapy)
- Retrospective Studies
- Treatment Outcome
|