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Resveratrol inhibits glioma cell growth via targeting oncogenic microRNAs and multiple signaling pathways.

Abstract
Resveratrol (Res), a natural polyphenolic compound, has anticancer activity in a variety of cancers. In the present study, the antitumor effect and underlying molecular mechanism of Res on rat C6 glioma growth was studied. The results demonstrated that Res inhibited glioma cell proliferation, arrested cell cycle in S phase and induced apoptosis in vitro. Res also suppressed intracranial C6 tumor growth in vivo and prolonged survival in a fraction of the rats bearing intracranial gliomas. Res significantly downregulated the specific miRs, including miR-21, miR-30a-5p and miR-19, which have been identified as oncomiRs in our previous studies, and altered the expression of their targeting and crucial genes for glioma formation and progression such as p53, PTEN, EGFR, STAT3, COX-2, NF-κB and PI3K/AKT/mTOR pathway. Therefore, the anti-glioma effect of Res, at least in part, is through the regulation of oncogenic miRNAs. The effect of Res on non-coding RNAs should be studied further. Res is a potential multi-targeting drug for the treatment of gliomas.
AuthorsGuangxiu Wang, Fang Dai, Kai Yu, Zhifan Jia, Anling Zhang, Qiang Huang, Chunsheng Kang, Hao Jiang, Peiyu Pu
JournalInternational journal of oncology (Int J Oncol) Vol. 46 Issue 4 Pg. 1739-47 (Apr 2015) ISSN: 1791-2423 [Electronic] Greece
PMID25646654 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • MicroRNAs
  • Stilbenes
  • Resveratrol
Topics
  • Animals
  • Antineoplastic Agents, Phytogenic (administration & dosage, pharmacology)
  • Apoptosis
  • Brain Neoplasms (drug therapy, genetics, metabolism)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Down-Regulation
  • Glioma (drug therapy, genetics, metabolism)
  • MicroRNAs (genetics)
  • Rats
  • Resveratrol
  • Signal Transduction (drug effects)
  • Stilbenes (administration & dosage, pharmacology)
  • Xenograft Model Antitumor Assays

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