Multifunctional ultrasmall nanoplatforms for vascular-targeted interstitial photodynamic therapy of brain tumors guided by real-time MRI.

Abstract

Photodynamic therapy (PDT) for brain tumors appears to be complementary to conventional treatments. A number of studies show the major role of the vascular effect in the tumor eradication by PDT. For interstitial PDT (iPDT) of brain tumors guided by real-time imaging, multifunctional nanoparticles consisting of a surface-localized tumor vasculature targeting neuropilin-1 (NRP-1) peptide and encapsulated photosensitizer and magnetic resonance imaging (MRI) contrast agents, have been designed. Nanoplatforms confer photosensitivity to cells and demonstrate a molecular affinity to NRP-1. Intravenous injection into rats bearing intracranial glioma exhibited a dynamic contrast-enhanced MRI for angiogenic endothelial cells lining the neovessels mainly located in the peripheral tumor. By using MRI completed by NRP-1 protein expression of the tumor and brain adjacent to tumor tissues, we checked the selectivity of the nanoparticles. This study represents the first in vivo proof of concept of closed-head iPDT guided by real-time MRI using targeted ultrasmall nanoplatforms. From the clinical editor: The authors constructed tumor vascular peptide targeting multifunctional silica-based nanoparticles, with encapsulated gadolinium oxide as MRI contrast agent and chlorin as a photosensitizer, as a proof of concept novel treatment for glioblastoma in an animal model.

• Authors: Denise Bechet, Florent Auger, Pierre Couleaud, Eric Marty, Laura Ravasi, Nicolas Durieux, Corinne Bonnet, François Plénat, Céline Frochot, Serge Mordon, Olivier Tillement, Régis Vanderesse, François Lux, Pascal Perriat, François Guillemin, Muriel Barberi-Heyob
• Journal: Nanomedicine : nanotechnology, biology, and medicine (Nanomedicine) Vol. 11 Issue 3 Pg. 657-70 (Apr 2015) ISSN: 1549-9642 [Electronic] United States
• PMID: 25645959 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Photosensitizing Agents
• Neuropilin-1

Topics

• Animals
• Brain Neoplasms (diagnostic imaging, drug therapy)
• Cell Line, Tumor
• Female
• Glioma (diagnostic imaging, drug therapy)
• Humans
• Magnetic Resonance Angiography
• Nanoparticles (chemistry, therapeutic use)
• Neuropilin-1 (chemistry, therapeutic use)
• Photochemotherapy (methods)
• Photosensitizing Agents (chemistry, pharmacology)
• Radiography
• Rats
• Rats, Nude