Abstract | BACKGROUND: OBJECTIVE: PATIENTS AND METHODS:
Hydroperoxide formation in air-exposed linalyl acetate was determined with high-performance liquid chromatography. The sensitization potencies of hydroperoxides were determined with the local lymph node assay. One thousand seven hundred and seventeen patients were patch tested with oxidized linalyl acetate at 6.0% in petrolatum. RESULTS: Of the patients, 2.2% showed positive reactions to oxidized linalyl acetate. Forty-three per cent of the positive patients also had positive patch test reactions to other fragrance markers. Linalyl acetate hydroperoxides were detected early in the autoxidation process, and accumulated to a concentration of 37% after 42 weeks of air exposure. The linalyl acetate hydroperoxides were classified as moderate sensitizers. CONCLUSIONS:
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Authors | Lina Hagvall, Victoria Berglund, Johanna Bråred Christensson |
Journal | Contact dermatitis
(Contact Dermatitis)
Vol. 72
Issue 4
Pg. 216-23
(Apr 2015)
ISSN: 1600-0536 [Electronic] England |
PMID | 25645423
(Publication Type: Journal Article)
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Copyright | © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Allergens
- Monoterpenes
- Perfume
- linalyl acetate
- Hydrogen Peroxide
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Topics |
- Air
- Allergens
(chemistry, immunology)
- Animals
- Chromatography, High Pressure Liquid
- Dermatitis, Allergic Contact
(etiology)
- Female
- Humans
- Hydrogen Peroxide
(analysis, immunology)
- Local Lymph Node Assay
- Male
- Mice
- Monoterpenes
(chemistry, immunology)
- Oxidation-Reduction
- Patch Tests
- Perfume
(adverse effects, chemistry)
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