Abstract | PURPOSE: METHODS: A retrospective review of patients with threshold retinopathy of prematurity treated between January 2001 and October 2012 was conducted. Single-spot laser treatment or confluent laser treatment was applied anterior to the ridge extending to the ora serrata. In the first group (the single-spot group), a single-spot DLC was used between January 2001 and May 2008. The single-spot group included 338 patients (671 eyes) with retinopathy of prematurity. In the second group (the confluent group), confluent DLC was used in 326 patients (652 eyes) between June 2008 and October 2012. The authors compared the need for re-treatment to achieve regression of retinopathy of prematurity in both groups. The rate of progression, frequency of re-treatment, complications, and structural outcomes were evaluated. RESULTS: In the single-spot group, re-treatment only with DLC was necessary in 43 (6.4%) eyes, additional cryotherapy was performed in 22 (3.3%) eyes, and scleral buckling in 107 (15.9%) eyes. Altogether, additional therapy was used in 172 (25.6%) eyes. In the confluent group, re-treatment with DLC was used in 5 (0.8%) eyes, additional cryotherapy in 6 (0.9%) eyes, scleral buckling in 16 (2.5%) eyes, and intravitreal bevacizumab in 14 (2.1%) eyes. Altogether, additional therapy was used in 41 (6.3%) eyes. The confluent group showed a favorable anatomical outcome in 99.1% of the cases compared with 96.4% in the single-spot group. The results were statistically significant (P = .001.) CONCLUSIONS:
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Authors | Zuzana Prepiaková, Dana Tomcíková, Barbora Kostolná, Anton Gerinec |
Journal | Journal of pediatric ophthalmology and strabismus
(J Pediatr Ophthalmol Strabismus)
2015 Jan-Feb
Vol. 52
Issue 1
Pg. 43-51
ISSN: 1938-2405 [Electronic] United States |
PMID | 25643370
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright 2015, SLACK Incorporated. |
Chemical References |
- Angiogenesis Inhibitors
- Antibodies, Monoclonal, Humanized
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- Bevacizumab
|
Topics |
- Angiogenesis Inhibitors
(therapeutic use)
- Antibodies, Monoclonal, Humanized
(therapeutic use)
- Bevacizumab
- Cryotherapy
- Gestational Age
- Humans
- Infant, Newborn
- Infant, Very Low Birth Weight
- Laser Coagulation
(methods)
- Lasers, Semiconductor
(therapeutic use)
- Reoperation
- Retinopathy of Prematurity
(physiopathology, surgery)
- Retrospective Studies
- Scleral Buckling
- Vascular Endothelial Growth Factor A
(antagonists & inhibitors)
- Visual Acuity
(physiology)
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