Ultrasmall Cu2-x S Nanodots for Highly Efficient Photoacoustic Imaging-Guided Photothermal Therapy.

Abstract

Monodisperse, ultrasmall (<5 nm) Cu(2-x)S nanodots (u-Cu(2-x)S NDs) with significantly strong near-infrared absorption and conversion are successfully demonstrated for effective deep-tissue photoacoustic imaging-guided photothermal therapy both in vitro and in vivo. Owing to ultrasmall nanoparticle size and high water dispersibility as well as long stability, such nanodots possess a prolonged circulation in blood and good passive accumulation within tumors through the enhanced permeability and retention effect. These u-Cu(2-x)S NDs have negligible side effects to both blood and normal tissues according to in vivo toxicity evaluations for up to 3 months, showing excellent hemo/histocompatibility. Furthermore, these u-Cu(2-x)S NDs can be thoroughly cleared through feces and urine within 5 days, showing high biosafety for further potential clinical translation. This novel photoacoustic imaging-guided photothermal therapy based on u-Cu(2-x)S NDs composed of a single component shows great prospects as a multifunctional nanoplatform with integration and multifunction for cancer diagnosis and therapy.

• Authors: Juan Mou, Pei Li, Chengbo Liu, Huixiong Xu, Liang Song, Jin Wang, Kun Zhang, Yu Chen, Jianlin Shi, Hangrong Chen
• Journal: Small (Weinheim an der Bergstrasse, Germany) (Small) Vol. 11 Issue 19 Pg. 2275-83 (May 20 2015) ISSN: 1613-6829 [Electronic] Germany
• PMID: 25641784 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Copper

Topics

• Animals
• Cell Survival (drug effects)
• Copper (chemistry)
• Diagnostic Imaging
• Female
• HeLa Cells
• Humans
• Hyperthermia, Induced
• Imaging, Three-Dimensional
• Metabolic Networks and Pathways (drug effects)
• Mice, Nude
• Nanoparticles (chemistry, toxicity, ultrastructure)
• Particle Size
• Photoacoustic Techniques (methods)
• Phototherapy