Epidemiologic findings concerning the association between the
hsa-mir-499 rs3746444 A>G polymorphism and
cancer risk have yielded mixed results. We aimed to investigate the association by performing a meta-analysis of all available studies. We searched PubMed and EMBASE for studies published up to November 2014, using odds ratios (
ORs) with 95% confidence intervals (CIs) to assess the strength of any association. The Benjamini- Hochberg (BH) method was used to correct the p values for multiple comparisons. We included 39 studies, including 14,136 cases and 16,937 controls. The results of overall meta-analysis suggested a borderline association between
hsa-mir-499 rs3746444 polymorphism and
cancer susceptibility (AG+GG vs. AA: OR=1.15, 95% CI= 1.04-1.26, corrected p value=0.04). After removing studies not conforming to Hardy-Weinberg equilibrium (HWE), however, this association disappeared (AG+GG vs AA: OR=1.18, 95% CI=1.03-1.34, corrected p value=0.21). When stratified analysis by ethnicity,
cancer type or HWE in controls, although some associations between
hsa-mir-499 rs3746444 polymorphism and
cancer susceptibility were detected, these associations no longer existed after adjustment using BH method. In conclusion, our meta-analysis suggests that
hsa-mir-499 rs3746444 A>G polymorphism is not associated with risk of
cancer based on current evidence.