Pro-C5, a marker of true type V collagen formation and fibrillation, correlates with portal hypertension in patients with alcoholic cirrhosis.

Abstract

BACKGROUND AND AIMS:

The hepatic venous pressure gradient (HVPG) is an important but invasive diagnostic and prognostic marker in cirrhotic patients. The aim of the study was to evaluate a novel biochemical plasma marker of true type V collagen formation (Pro-C5) for describing HVPG.

METHODS:

Ninety-four patients mainly with alcoholic cirrhosis and fourteen liver-healthy controls were included in a retrospective study. Relevant clinical and routine laboratory data and hemodynamics were determined. Plasma Pro-C5 was correlated to HVPG and liver function parameters. Furthermore, Pro-C5 was combined in a linear regression model.

RESULTS:

Plasma Pro-C5 correlated to HVPG, indocyanine green clearance, sustained vascular resistance and mean arterial pressure (r = -0.68-0.33, p < 0.0001). A multiple regression analysis including Pro-C5, alanine aminotransferase, bilirubin and model for end-stage liver disease (MELD) improved the correlation to HVPG (r = 0.74, p < 0.0001). Plasma Pro-C5 was positively or negatively correlated to a number of routine liver function markers and MELD score (r = 0.27-0.68; p < 0.05-0.0001). Furthermore, plasma Pro-C5 could clearly separate patients with a HVPG <10 mmHg or HVPG ≥10 mmHg (p < 0.001, area under the curve (AUC) = 0.73), HVPG 10-<16 mmHg or HVPG ≥16 mmHg (p < 0.001, AUC = 0.68) and controls from diseased patients (p < 0.0001, AUC = 0.88). Finally, there was a clear relation to increasing Child score A-C and plasma Pro-C5 (ANOVA p < 0.001).

CONCLUSION:

Plasma Pro-C5 reflects liver hemodynamics, liver function, disease stage and clinically significant portal hypertension (PH). A multimarker model in combination with clinical scores predicted HVPG and separated clinical relevant HVPG thresholds. Plasma Pro-C5 may be suitable for the noninvasive evaluation of PH in patients with cirrhosis.

• Authors: Diana J Leeming, Sanne S Veidal, Morten A Karsdal, Mette Juul Nielsen, Jonel Trebicka, Troels Busk, Flemming Bendtsen, Aleksander Krag, Søren Møller
• Journal: Scandinavian journal of gastroenterology (Scand J Gastroenterol) Vol. 50 Issue 5 Pg. 584-92 (May 2015) ISSN: 1502-7708 [Electronic] England
• PMID: 25639675 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Collagen Type V
• Complement C5
• Alanine Transaminase
• Bilirubin

Topics

• Aged
• Alanine Transaminase (blood)
• Area Under Curve
• Bilirubin (blood)
• Biomarkers (blood)
• Collagen Type V (chemistry)
• Complement C5 (chemistry)
• End Stage Liver Disease (complications)
• Female
• Humans
• Hypertension, Portal (diagnosis)
• Linear Models
• Liver Cirrhosis, Alcoholic (complications, diagnosis)
• Male
• Middle Aged
• ROC Curve
• Retrospective Studies