Abstract | INTRODUCTION: METHODS: Between 1997 and 2012, out of 426 patients with HCC in non-cirrhotic livers, 39 patients with BDTT (Group I n = 39), who underwent a hepatectomy, were analysed and compared with the non-BDTT group (Group II n = 387). RESULTS: The demographic profile and biochemical parameters between Group I and Group II were compared; apart from the presence of jaundice at presentation and an elevated serum bilirubin, there were no significant differences. Post-operative morbidity and mortality were 11 (28.2%) and 2 (5.1%), respectively, in Group I. There were no differences between the groups with regards to the operative variables and short-term outcomes. The 1-, 3- and 5-year survival rates in Group I were 82%, 48% and 10%, respectively, with a median survival of 28.6 months and were significantly poorer than Group II (90%, 55% and 38%, respectively, with a median survival of 39.2 months). CONCLUSION: The mere presence of BDTT in HCC does not indicate an advanced or inoperable lesion. When technically feasible, a formal hepatic resection is the preferred first-line treatment option in these patients.
|
Authors | Ashwin Rammohan, Jeswanth Sathyanesan, Kamalakannan Rajendran, Anbalagan Pitchaimuthu, Senthil K Perumal, Kesavan Balaraman, Ravi Ramasamy, Ravichandran Palaniappan, Manoharan Govindan |
Journal | HPB : the official journal of the International Hepato Pancreato Biliary Association
(HPB (Oxford))
Vol. 17
Issue 6
Pg. 508-13
(Jun 2015)
ISSN: 1477-2574 [Electronic] England |
PMID | 25639610
(Publication Type: Comparative Study, Journal Article)
|
Copyright | © 2015 International Hepato-Pancreato-Biliary Association. |
Topics |
- Adult
- Aged
- Bile Ducts
(pathology, surgery)
- Carcinoma, Hepatocellular
(complications, mortality, pathology, surgery)
- Cholestasis
(etiology, mortality, pathology, surgery)
- Female
- Hepatectomy
(adverse effects, methods, mortality)
- Humans
- Jaundice, Obstructive
(etiology, mortality, pathology, surgery)
- Kaplan-Meier Estimate
- Liver Neoplasms
(complications, mortality, pathology, surgery)
- Male
- Middle Aged
- Patient Selection
- Risk Factors
- Time Factors
- Treatment Outcome
|