The present studies focused on the evaluation of design of an adhesive
silicone film intended for
scar treatment. Developed
silicone double layer film was examined in terms of its future relevance to
therapy and applicability on the human skin considering properties which included in vitro permeability of
water vapor and
oxygen. In order to adapt the patches for medical use in the future there were tested such properties as in vitro adhesion and occlusion related to in vivo hydration. From the
silicone rubbers double layer
silicone film was prepared: a non-adhesive
elastomer as a
drug carrier (the matrix for active substances -
enoxaparin sodium -
low molecular weight heparin) and an adhesive
elastomer, applied on the surface of the matrix. The novel adhesive
silicone film was found to possess optimal properties in comparison to commercially available
silicone dressing: adhesion in vivo, adhesion in vitro - 11.79N, occlusion F=85% and
water vapor permeability in vitro - WVP=105g/m(2)/24h, hydration of stratum corneum in vivoH=61-89 (RSD=1.6-0.9%),
oxygen permeation in vitro - 119-391 cm(3)/m(2)/24 (RSD=0.17%). In vitro release studies indicated sufficient
LMWH release rate from
silicone matrix. Developed novel adhesive
silicone films were considered an effective treatment of
scars and
keloids and a potential
drug carrier able to improve the effectiveness of
therapy.