Antibacterial effect of butyryl alkannin from Arnebia euchroma against vancomycin-resistant pathogens of Enterococcus faecalis causing urinary tract infections.

Abstract

This study was carried out to investigate the biomedicinal potential of a bioactive marker component, butyryl alkannin, isolated from n-hexane root extract of Arnebia euchroma against various vancomycin-resistant Enterococcus (VRE) isolates of Enterococcus faecalis causing urinary tract infections. As a result, butyryl alkannin showed significant antibacterial activity against multidrug-resistant E. faecalis pathogens of VRE as minimum inhibitory concentration values which were found in the range of 3.13 to 6.26 μg ml(-1). The findings of this study justify biological and biomedicinal potential of butyryl alkannin compound as confirmed by its higher and significant antibacterial efficacy against VRE isolates of E. faecalis as compared to standard antibiotic vancomycin.

• Authors: Lokesh Kumar Singh, Dinesh Kumar Maheshwari, Shruti Shukla
• Journal: Natural product research (Nat Prod Res) Vol. 29 Issue 24 Pg. 2299-301 ( 2015) ISSN: 1478-6427 [Electronic] England
• PMID: 25635653 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Naphthoquinones
• Plant Extracts
• alkannin

Topics

• Anti-Bacterial Agents (pharmacology)
• Boraginaceae (chemistry)
• Enterococcus faecalis (drug effects)
• Microbial Sensitivity Tests
• Molecular Structure
• Naphthoquinones (pharmacology)
• Plant Extracts (pharmacology)
• Plant Roots (chemistry)
• Urinary Tract Infections (microbiology)
• Vancomycin Resistance