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Modulation of peroxisome proliferator-activated receptor gamma (PPAR γ) by conjugated fatty acid in obesity and inflammatory bowel disease.

Abstract
Conjugated fatty acids including conjugated linoleic acid (CLA) and conjugated linolenic acid (CLNA) have drawn significant attention for their variety of biologically beneficial effects. Evidence suggested that CLA and CLNA could play physiological roles by regulating the expression and activity of PPAR γ. This review summarizes the current understanding of evidence of the role of CLA (cis-9,trans-11 CLA and trans-10,cis-12 CLA) and CLNA (punicic acid and α-eleostearic acid) in modulating the expression or activity of PPAR γ that could in turn be employed as complementary treatment for obesity and inflammatory bowel disease.
AuthorsGaofeng Yuan, Xiaoe Chen, Duo Li
JournalJournal of agricultural and food chemistry (J Agric Food Chem) Vol. 63 Issue 7 Pg. 1883-95 (Feb 25 2015) ISSN: 1520-5118 [Electronic] United States
PMID25634802 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Fatty Acids
  • Linoleic Acids, Conjugated
  • PPAR gamma
Topics
  • Animals
  • Fatty Acids (metabolism)
  • Humans
  • Inflammatory Bowel Diseases (genetics, metabolism)
  • Linoleic Acids, Conjugated (metabolism)
  • Obesity (genetics, metabolism)
  • PPAR gamma (genetics, metabolism)

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