Abstract | BACKGROUND: METHOD: This is a prospective, multicentric, hospital registry of 1000 patients with ACS undergoing PCI who were administered Prasugrel. The primary safety endpoint of this study was major and minor bleeding while the efficacy endpoint is the composite of CV death, nonfatal MI, nonfatal stroke up to 30 days after PCI. Patients with high bleeding risk were excluded. RESULTS: Most patients (91%) received loading dose of Prasugrel along with the maintenance dose getting according to the defined protocol. Patients were followed up to 30 days post procedure. Primary efficacy end point was reached in 3 patients only with two of them dying due to possible stent thrombosis and the third requiring revascularization of the target vessel for stent thrombosis. One major and 19 minor bleeding complications were recorded, with access site bleeding in 0.7% & non-access site bleeding in 1.2% of the subjects. CONCLUSION:
Prasugrel was found to be effective & not associated with a high incidence of bleeding in the high risk ACS patients when those at a high bleeding risk were excluded.
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Authors | Upendra Kaul, Arvind Sethi, P Arambam, A K Omar, R Keshava, Sanjeeb Roy, Shuvanan Ray, Rakesh Jaswal, Ripan K Gupta, Rakesh Rai Sapra, Rane Sandip Keshav, Rajpal Singh, Vineet Bhatia, Vinay Sanghi, Arun Chopra |
Journal | Indian heart journal
(Indian Heart J)
2014 Nov-Dec
Vol. 66
Issue 6
Pg. 598-601
ISSN: 2213-3763 [Electronic] India |
PMID | 25634391
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Cardiological Society of India. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Platelet Aggregation Inhibitors
- Prasugrel Hydrochloride
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Topics |
- Acute Coronary Syndrome
(surgery)
- Female
- Humans
- India
- Male
- Middle Aged
- Percutaneous Coronary Intervention
- Platelet Aggregation Inhibitors
(administration & dosage, adverse effects)
- Prasugrel Hydrochloride
(administration & dosage, adverse effects)
- Registries
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