Scabies is found worldwide among people of all groups and ages. It is curable with scabicide medications. This study aimed to compare the efficacy and safety of oral
ivermectin vs
malathion 0.5% lotion for the treatment of
scabies. In total, 148 patients with
scabies were enrolled and randomized into two groups: the first group received a single dose of oral
ivermectin 200 sg/kg
body weight, and the second was treated with two applications of topical
lindane lotion 1%, with a 1-week interval between applications. Treatment was evaluated at intervals of 2 and 4 weeks, and if there was treatment failure at the 2-week follow-up, treatment was repeated. A single dose of
ivermectin provided a cure rate of 60.8% at the 2-week follow-up, which increased to 89.1% at the 4-week follow-up after repeating the treatment. Treatment with two applications oflindane lotion 1%, with a 1-week interval between them, was effective in 47.2% of patients at the 2-week follow-up, which increased to 72.9% at the 4-week follow-up after this treatment was repeated. A single dose of
ivermectin was as effective as two applications of
lindane lotion 1% at the 2-week follow-up. After repeat treatment,
ivermectin was superior to
lindane lotion 1% at the 4-week follow-up. The delay in clinical response with
ivermectin suggests that it may not be effective against the parasite at all stages in the life cycle.