Abstract | OBJECTIVES: METHODS: We retrospectively analysed patients with proven vascular and ocular pythiosis in King Chulalongkorn Memorial Hospital from April 2003 to May 2013. Fisher's exact test and Wilcoxon's rank-sum test were used. The MICs of seven antifungal agents and combination drugs were investigated in eight clinical Pythium insidiosum strains. RESULTS: Eighteen patients were evaluated. Disease-free surgical margins were obtained in all surviving patients with vascular pythiosis (P = 0.08). Patients who underwent eye enucleation were significantly older than those who did not (P < 0.05). Patients with vascular or ocular pythiosis did not differ significantly in the median time from disease onset to first surgery or in the relationship between the type of P. insidiosum antigen and treatment outcomes. In vitro susceptibility profiles of all isolates demonstrated that no single agent or combination treatment was substantially more effective than the others. The highest MIC was detected for amphotericin B, followed in order by voriconazole, fluconazole, anidulafungin, caspofungin, itraconazole and terbinafine. No synergistic effects of the combination drug treatments were found. CONCLUSIONS:
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Authors | Nitipong Permpalung, Navaporn Worasilchai, Rongpong Plongla, Sikarin Upala, Anawin Sanguankeo, Leilani Paitoonpong, Leonel Mendoza, Ariya Chindamporn |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 70
Issue 6
Pg. 1885-92
( 2015)
ISSN: 1460-2091 [Electronic] England |
PMID | 25630647
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © The Author 2015. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: [email protected]. |
Chemical References |
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Topics |
- Adult
- Antifungal Agents
(therapeutic use)
- Debridement
- Eye Diseases
(drug therapy, surgery)
- Female
- Humans
- Immunotherapy
(methods)
- Male
- Microbial Sensitivity Tests
- Middle Aged
- Pythiosis
(drug therapy, surgery)
- Retrospective Studies
- Treatment Outcome
- Vascular Diseases
(drug therapy, surgery)
- Young Adult
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