Efficacy and toxicity of N,N',N",N"'-tetra(2,3,4-trihydroxybenzoyl)-spermine for decorporation of 239Pu from mice.

Abstract

Male SAS/4 mice were injected i.v. with 6.6 kBq 239Pu-citrate. After 1 or 24 h a single i.p. injection of 15 or 30 mumol kg-1 or repeated (three or four) daily injections of 30 mumol kg-1 of tetra-THB-spermine were given, and at 4 or 7 days Pu retention was measured in liver, kidneys and femur. Besides tetra-THB-spermine, equimolar doses of tetra-DHB-spermine were injected for comparison, or equimolar doses of diethylene triamine-pentaacetic acid (DTPA) as a reference compound. Histological changes in kidneys and liver were examined after i.p. injections of 30 mumol kg-1 or at 2-13 times higher doses of tetra-THB-spermine. The results show that: (1) Introduction of an additional hydroxy group into the aromatic moieties of tetra-DHB-spermine results in increased hydrophilicity, lower toxicity and a lower renal retention of Pu. (2) Tetra-THB-spermine and tetra-DHB-spermine are similarly effective in removing plutonium from liver and bone. Their efficacies in removing Pu from bone are approximately similar to those of DTPA but for whole-body removal they are generally inferior. (3) Multiple (30 mumol kg-1) of tetra-THB-spermine were no more effective than a single injection at mobilizing Pu from the liver. (4) Four injections of tetra-THB-spermine induced cloudy swelling and fatty degeneration in epithelial cells of the proximal convoluted tubules. At levels of 400 mumol kg-1 tetra-THB-spermine produced severe degenerative glomerular lesions, foci of liver necrosis and thromboses of the portal vein branch.

• Authors: Z Szot, M Rochalska, K Chomiczewski, A Chimiak, W Przychodzeń
• Journal: International journal of radiation biology (Int J Radiat Biol) Vol. 55 Issue 1 Pg. 141-9 (Jan 1989) ISSN: 0955-3002 [Print] England
• PMID: 2562970 (Publication Type: Journal Article)

Chemical References

• Chelating Agents
• N,N',N'',N'''-tetra(2,3,4-trihydroxybenzoyl)spermine
• Spermine
• Plutonium
• LICAM-C
• Pentetic Acid
• Spermidine

Topics

• Animals
• Bone and Bones (metabolism)
• Chelating Agents (pharmacology, toxicity)
• Kidney (metabolism)
• Liver (metabolism)
• Male
• Mice
• Pentetic Acid (pharmacology)
• Plutonium (pharmacokinetics)
• Spermidine (analogs & derivatives, pharmacology)
• Spermine (analogs & derivatives, pharmacology, toxicity)