Surgery in the era of the 'omics revolution.

Abstract

BACKGROUND:

Surgery is entering a new phase with the revolution in genomic technology. Cheap, mass access to next-generation sequencing is now allowing the analysis of entire human genomes at the DNA and RNA level. These data sets are being used increasingly to identify the molecular differences that underlie common surgical diseases, and enable them to be stratified for patient benefit.

METHODS:

This article reviews the recent developments in the molecular biology of colorectal, oesophagogastric and breast cancer.

RESULTS:

The review specifically covers developments in genetic predisposition, next-generation sequencing studies, biomarkers for stratification, prognosis and treatment, and other 'omics technologies such as metabolomics and proteomics.

CONCLUSION:

There are unique opportunities over the next decade to change the management of surgical disease radically, using these technologies. The directions that this may take are highlighted, including future advances such as the 100,000 Genomes Project.

• Authors: A D Beggs, M P Dilworth
• Journal: The British journal of surgery (Br J Surg) Vol. 102 Issue 2 Pg. e29-40 (Jan 2015) ISSN: 1365-2168 [Electronic] England
• PMID: 25627134 (Publication Type: Journal Article, Review)
• Copyright: © 2015 The Authors. BJS published by JohnWiley & Sons Ltd on behalf of BJS Society Ltd.

Chemical References

• Biomarkers, Tumor

Topics

• Biomarkers, Tumor (analysis)
• Breast Neoplasms (genetics, surgery)
• Early Detection of Cancer (methods, trends)
• Female
• Forecasting
• Gastrointestinal Neoplasms (genetics, surgery)
• Genetic Predisposition to Disease (genetics)
• Genetic Testing (methods, trends)
• Genome-Wide Association Study (methods, trends)
• Genomics (methods, trends)
• Humans
• Inventions (trends)
• Metabolomics (trends)
• Molecular Targeted Therapy (methods, trends)
• Mutation (genetics)
• Prognosis
• Therapies, Investigational (methods, trends)