Abstract |
Primary pulmonary mucin-rich lesions with abundant goblet cells growing within alveolar spaces are either classified as mucinous adenocarcinoma (previously called mucinous bronchioloalveolar carcinoma) or colloid carcinoma. Some of these lesions display a morphologic pattern characterized by paucicellular discontinuous patches of nonatypical colonic type epithelium attached to alveolar walls without evidence of invasion. Immunohistochemically, these epithelial patches express an intestinal immunophenotype (CD20+, CDX-2+, CK7-, TTF-1-). None of the lesions so far reported with these histological and immunohistochemical characteristics have recurred or metastasized. Herein we describe 2 patients with this type of intra-alveolar mucinous lesions who have been meticulously followed-up for 9 and 14 years, respectively, without evidence of disease progression. Based on their histologic appearance, immunoreactivity, and on the presence of occasional CDX-2 expressing cells in terminal airways adjacent to the lesions, we propose alternative interpretations of the mucin-producing epithelium. More important, a separate provisional category for these lesions is suggested that eliminates their force inclusion as adenocarcinomas.
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Authors | Jose Jessurun |
Journal | International journal of surgical pathology
(Int J Surg Pathol)
Vol. 23
Issue 3
Pg. 196-201
(May 2015)
ISSN: 1940-2465 [Electronic] United States |
PMID | 25627070
(Publication Type: Case Reports, Journal Article, Review)
|
Copyright | © The Author(s) 2015. |
Chemical References |
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Topics |
- Adenocarcinoma, Mucinous
(pathology)
- Biomarkers, Tumor
(analysis)
- Female
- Humans
- Immunohistochemistry
- Lung Neoplasms
(pathology)
- Middle Aged
- Young Adult
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