Hypo- or hyper-hippo: a balancing act with bHLH transcription factors.

Abstract

Balancing cell growth with differentiation is essential for tissue integrity. In this issue of Developmental Cell, Wang and Baker (2015) demonstrate unsuspected cross-talk between bHLH transcription factors, important regulators of organogenesis, with the Hippo tumor suppressor pathway to ensure that inappropriately differentiating cells are eliminated during development.

• Authors: Tiffany A Cook
• Journal: Developmental cell (Dev Cell) Vol. 32 Issue 2 Pg. 133-5 (Jan 26 2015) ISSN: 1878-1551 [Electronic] United States
• PMID: 25625203 (Publication Type: Journal Article, Comment)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Cell Cycle Proteins
• Drosophila Proteins
• Intracellular Signaling Peptides and Proteins
• sav protein, Drosophila
• Protein Kinases
• wts protein, Drosophila
• Protein Serine-Threonine Kinases
• hpo protein, Drosophila

Topics

• Animals
• Cell Cycle Checkpoints (physiology)
• Cell Cycle Proteins (metabolism)
• Drosophila Proteins (metabolism)
• Drosophila melanogaster (metabolism)
• Intracellular Signaling Peptides and Proteins (metabolism)
• Protein Kinases (metabolism)
• Protein Serine-Threonine Kinases (metabolism)
• Signal Transduction