Abstract | INTRODUCTION: MATERIAL AND METHODS: RESULTS: Natural allergen stimulation resulted in a significant increase of TNS-4 (p < 0.001) and nasal eosinophilia (p < 0.001). The concentration of PGE2 dominated in the NALF outside the pollen season and decreased significantly at the height of natural exposure (p < 0.01). In contrast, lower baseline concentrations of cys-LTs and 8-isoprostane increased significantly upon allergen stimulation (p < 0.05). There was a significant correlation between mean concentration of PGE2 and eosinophil number in NALF (r = 0.67, p = 0.0439). CONCLUSIONS: The NALF concentrations of cys-LTs and 8-isoprostane change simultaneously with TNS-4 and nasal eosinophilia. However, due to the lack of any significant correlation, their utility as markers of allergic rhinitis should be warily considered. The decrease of PGE2 concentration in NALF which correlated with nasal eosinophilia may participate in escalation of allergic inflammation and needs further evaluation.
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Authors | Maciej Ciebiada, Paweł Górski, Adam Antczak |
Journal | Archives of medical science : AMS
(Arch Med Sci)
Vol. 10
Issue 6
Pg. 1123-8
(Dec 22 2014)
ISSN: 1734-1922 [Print] Poland |
PMID | 25624848
(Publication Type: Journal Article)
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