Early hyperbaric oxygen therapy inhibits aquaporin 4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral injury.

Abstract

In the present study, rabbits were treated with hyperbaric oxygen for 1 hour after detonator-blast- induced craniocerebral injury. Immunohistochemistry showed significantly reduced aquaporin 4 expression and adrenocorticotropic hormone expression in the pituitary gland of rabbits with craniocerebral injury. Aquaporin 4 expression was positively correlated with adrenocorticotropic hormone expression. These findings indicate that early hyperbaric oxygen therapy may suppress adrenocorticotropic hormone secretion by inhibiting aquaporin 4 expression.

• Authors: Jian Huo, Jiachuan Liu, Jinbiao Wang, Yongming Zhang, Chunlin Wang, Yanyan Yang, Wenjiang Sun, Shaonian Xu
• Journal: Neural regeneration research (Neural Regen Res) Vol. 7 Issue 22 Pg. 1729-35 (Aug 05 2012) ISSN: 1673-5374 [Print] India
• PMID: 25624795 (Publication Type: Journal Article)