Abstract |
Brain amyloid depositions are the main hallmarks of Alzheimer's and other protein misfolding diseases. Since they are believed to precede clinical symptoms by several years, imaging of such fibrillar aggregates is particularly suitable to diagnose the onset of the disease in its early stage and monitor its progression. In this context, near infrared (NIR) imaging has been proposed as a promising and non-invasive method to visualize amyloid plaques in vivo because of its acceptable depth of penetration and minimal degree of tissue damage. In this tutorial review, we describe the main chemical and physicochemical features of probes associated with fluorescence emission in the NIR region. The review focuses on the recent progress and improvements in the development of small-molecule NIR fluorescent probes and their in vivo application in living animals. In addition, the possible therapeutic application of NIR probes to block the pathological aggregation process will be discussed, raising the fascinating possibility of their exploitation as theranostic agents.
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Authors | Matteo Staderini, María Antonia Martín, Maria Laura Bolognesi, J Carlos Menéndez |
Journal | Chemical Society reviews
(Chem Soc Rev)
Vol. 44
Issue 7
Pg. 1807-19
(Apr 07 2015)
ISSN: 1460-4744 [Electronic] England |
PMID | 25622714
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Amyloid beta-Peptides
- Fluorescent Dyes
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Topics |
- Amyloid beta-Peptides
(analysis)
- Animals
- Fluorescent Dyes
(chemistry)
- Humans
- Mice
- Mice, Transgenic
- Neurosciences
- Plaque, Amyloid
- Spectroscopy, Near-Infrared
(methods)
- Theranostic Nanomedicine
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