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Urinary phthalate metabolites are associated with insulin resistance in obese subjects.

Abstract
Phthalates are potentially involved in the development of type 2 diabetes mellitus. In a cohort of 123 obese subjects, 10 phthalate metabolites were analyzed. An oral glucose tolerance test was performed and various estimates of insulin resistance and beta-cell function were calculated. After adjustment for age, physical activity level, smoking behavior, medication use and body mass index, several phthalate metabolites were linked to markers of glucose tolerance and insulin resistance.
AuthorsEveline Dirinck, Alin C Dirtu, Tinne Geens, Adrian Covaci, Luc Van Gaal, Philippe G Jorens
JournalEnvironmental research (Environ Res) Vol. 137 Pg. 419-23 (Feb 2015) ISSN: 1096-0953 [Electronic] Netherlands
PMID25622280 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier Inc. All rights reserved.
Chemical References
  • Blood Glucose
  • Phthalic Acids
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Belgium
  • Blood Glucose (metabolism)
  • Cohort Studies
  • Female
  • Glucose Tolerance Test
  • Humans
  • Insulin Resistance
  • Male
  • Middle Aged
  • Obesity (etiology, physiopathology)
  • Overweight (etiology, physiopathology)
  • Phthalic Acids (urine)
  • Young Adult

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