Abstract | BACKGROUND: The term orofacial granulomatosis is conventionally used to describe patients with granulomatous lesions affecting the orofacial tissues, in absence of intestinal lesions. Lip swelling and facial swelling are the most common clinical signs. Despite the fact that histologically it is not distinguishable from Crohn's disease, and that both diseases have a chronic/recurrent course, the relationship between orofacial granulomatosis and Crohn's disease is still debated. METHODS: RESULTS: All patients presented concomitant Crohn's disease, supporting the hypothesis that orofacial granulomatosis and Crohn's disease may be one single disease. Thalidomide was effective in inducing remission of oral and intestinal symptoms in all five cases and could be considered a valid treatment opportunity for these patients. CONCLUSIONS:
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Authors | Marzia Lazzerini, Stefano Martelossi, Gabriele Cont, Chiara Bersanini, Giovanna Ventura, Massimo Fontana, Giovanna Zuin, Alessandro Ventura, Andrea Taddio |
Journal | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
(Dig Liver Dis)
Vol. 47
Issue 4
Pg. 338-41
(Apr 2015)
ISSN: 1878-3562 [Electronic] Netherlands |
PMID | 25618553
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2014 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Immunosuppressive Agents
- Thalidomide
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Topics |
- Adolescent
- Biopsy
- Child
- Colonoscopy
- Crohn Disease
(complications, diagnosis, drug therapy)
- Diagnosis, Differential
- Female
- Granulomatosis, Orofacial
(complications, diagnosis, drug therapy)
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Male
- Thalidomide
(therapeutic use)
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