VIP-helodermin receptors in the murine virus-induced T lymphoma cell line BL/VL3 recover less rapidly than beta-adrenoceptors after down regulation.

Abstract

The time course of recovery of beta-adrenergic and VIP/helodermin receptors after homologous and heterologous down regulation was studied in the murine lymphoma cell line BL/VL3, a neoplastic equivalent of immature T cells. The heterologous part of isoproterenol down regulation was rapidly reversed, even in the presence of cycloheximide, suggesting that down regulation was linked to ligand-receptor interaction and/or cyclic AMP increase. Homologous down regulations of beta-adrenoceptors and VIP/helodermin receptors were less rapidly reversible and depended on protein synthesis as they were inhibited by cycloheximide: beta-adrenoceptors recovered faster than VIP/helodermin receptors.

• Authors: C Damien, P Robberecht, J Abello, R Hooghe, J Christophe
• Journal: Journal of receptor research (J Recept Res) 1989-1990 Vol. 9 Issue 6 Pg. 441-9 ISSN: 0197-5110 [Print] United States
• PMID: 2561794 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Intercellular Signaling Peptides and Proteins
• Peptides
• Receptors, Adrenergic, beta
• Receptors, Gastrointestinal Hormone
• Receptors, Vasoactive Intestinal Peptide
• Vasoactive Intestinal Peptide
• heliodermin
• Adenylyl Cyclases
• Isoproterenol

Topics

• Adenylyl Cyclases (metabolism)
• Animals
• Cell Line, Transformed
• Cell Transformation, Viral
• Down-Regulation (physiology)
• Intercellular Signaling Peptides and Proteins
• Isoproterenol (pharmacology)
• Lymphoma
• Mice
• Peptides (pharmacology)
• Receptors, Adrenergic, beta (physiology)
• Receptors, Gastrointestinal Hormone (physiology)
• Receptors, Vasoactive Intestinal Peptide
• T-Lymphocytes (metabolism)
• Vasoactive Intestinal Peptide