The advanced glycation end product methylglyoxal-derived hydroimidazolone-1 and early signs of atherosclerosis in childhood diabetes.

Abstract

BACKGROUND:

Advanced protein glycation is an important mechanism for the development of late diabetic complications including atherosclerosis. Methylglyoxal-derived hydroimidazolone-1 is the most abundant advanced glycation end product in human plasma.

AIM:

To investigate the relationship between methylglyoxal-derived hydroimidazolone-1 and early signs of atherosclerosis in children and adolescents with type 1 diabetes and healthy controls.

METHODS:

A total of 314 diabetes patients aged 8-18 years were compared with 120 healthy controls. Serum methylglyoxal-derived hydroimidazolone-1 was measured by immunoassay. Atherosclerosis was evaluated by assessing carotid intima-media thickness by ultrasound, arterial stiffness by Young's modulus and inflammation by C-reactive protein.

RESULTS:

Methylglyoxal-derived hydroimidazolone-1 was significantly increased in the diabetes group compared with controls, 155.3 (standard deviation (SD) = 41.0) versus 143.0 (SD = 35.1) U/mL, p = 0.003, as was C-reactive protein, median 0.51 (0.27, 1.83) versus 0.31 (0.19, 0.67) mg/L, p < 0.001. There was no significant difference between the groups regarding carotid intima-media thickness or Young's modulus. Multiple regression analysis showed a significant positive association between methylglyoxal-derived hydroimidazolone-1 and C-reactive protein in the diabetes group.

CONCLUSION:

Serum levels of methylglyoxal-derived hydroimidazolone-1 in diabetes patients are increased and associated with low-grade inflammation, but not yet arterial stiffness or wall thickness. This indicates that methylglyoxal-derived hydroimidazolone-1 may be important in the early phase of the accelerated atherosclerotic process in diabetes.

• Authors: Martin Heier, Hanna Dis Margeirsdottir, Peter Abusdal Torjesen, Ingebjørg Seljeflot, Knut Haakon Stensæth, Mario Gaarder, Cathrine Brunborg, Kristian Folkvord Hanssen, Knut Dahl-Jørgensen
• Journal: Diabetes & vascular disease research (Diab Vasc Dis Res) Vol. 12 Issue 2 Pg. 139-45 (Mar 2015) ISSN: 1752-8984 [Electronic] England
• PMID: 25616705 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2015.

Chemical References

• Biomarkers
• Imidazoles
• Inflammation Mediators
• imidazolone
• C-Reactive Protein

Topics

• Adolescent
• Age Factors
• Biomarkers (blood)
• C-Reactive Protein (analysis)
• Carotid Artery Diseases (blood, diagnosis, physiopathology)
• Carotid Intima-Media Thickness
• Case-Control Studies
• Child
• Diabetes Mellitus, Type 1 (blood, diagnosis)
• Diabetic Angiopathies (blood, diagnosis, physiopathology)
• Early Diagnosis
• Elastic Modulus
• Female
• Humans
• Imidazoles (blood)
• Immunoassay
• Inflammation Mediators (blood)
• Male
• Predictive Value of Tests
• Prognosis
• Risk Factors
• Up-Regulation
• Vascular Stiffness