Abstract |
Rat liver DNA was labelled with [methyl-3H] thymidine after partial hepatectomy, carbon tetrachloride poisoning, or an intravenous injection of silica dust. Changes in DNA labelling were studied for 4 weeks after the single pulse. Total radioactivity incorporated into liver DNA after partial hepatectomy and after carbon tetrachloride administration remained on the same level when compared with that found after 1 h. DNA activity in liver of untreated rats and of rats treated with silica decreased by about 50% within the first 2 weeks and then remained on this level for the rest of the studied period. These differences may reflect the fact that hepatocytes that have a long life span are preferentially labelled in partially hepatectomized and CCl4-treated rats, while liver macrophages with a short half-life take up a large part of the label in intact rats and in rats treated with silica.
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Authors | J Kanta, V Chmelar |
Journal | Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove
(Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove)
Vol. 32
Issue 4
Pg. 395-401
( 1989)
ISSN: 0049-5514 [Print] Czech Republic |
PMID | 2561578
(Publication Type: Journal Article)
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Chemical References |
- Dust
- Silicon Dioxide
- DNA
- Carbon Tetrachloride
- Thymidine
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Topics |
- Animals
- Carbon Tetrachloride
(toxicity)
- DNA
(drug effects, metabolism)
- Dust
(adverse effects)
- Female
- Hepatectomy
- Liver
(drug effects, metabolism)
- Liver Regeneration
- Rats
- Rats, Inbred Strains
- Silicon Dioxide
(adverse effects)
- Thymidine
(metabolism)
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